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The reaction mechanism studies by control experiments and using O 18-labelled water revealed that the reaction was initiated by attack of a conjugate base of aryl/heteroaryl methyl ketones (2 a–k) to aldehyde group of 1 a–h followed by intramolecular oxidative cyclization involving nitrile functionality to furnish isoindolinone derivatives. Join Facebook to connect with Hardeep Hunjan and others you may know. View Harpreet K. Join Facebook to connect with Raman Hunjan and others you may know. Rajinder Singh Hunjan is on Facebook. Hunjan Hunjan is on Facebook. Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Educational and Research (NIPER), S. 3K followers, 3. QQ plot and visualization of differentially expressed genes. An oxidative alkenylation of N. 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